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Towards host-directed therapies for tuberculosis.

Authors :
Zumla A
Maeurer M
Chakaya J
Hoelscher M
Ntoumi F
Rustomjee R
Vilaplana C
Yeboah-Manu D
Rasolof V
Munderi P
Singh N
Aklillu E
Padayatchi N
Macete E
Kapata N
Mulenga M
Kibiki G
Mfinanga S
Nyirenda T
Maboko L
Garcia-Basteiro A
Rakotosamimanana N
Bates M
Mwaba P
Reither K
Gagneux S
Edwards S
Mfinanga E
Abdulla S
Cardona PJ
Russell JB
Gant V
Noursadeghi M
Elkington P
Bonnet M
Menendez C
Dieye TN
Diarra B
Maiga A
Aseffa A
Parida S
Wejse C
Petersen E
Kaleebu P
Oliver M
Craig G
Corrah T
Tientcheu L
Antonio M
Rao M
McHugh TD
Sheikh A
Ippolito G
Ramjee G
Kaufmann SH
Churchyard G
Steyn A
Grobusch M
Sanne I
Martinson N
Madansein R
Wilkinson RJ
Mayosi B
Schito M
Wallis RS
Source :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2015 Aug; Vol. 14 (8), pp. 511-2. Date of Electronic Publication: 2015 Jul 17.
Publication Year :
2015

Abstract

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

Details

Language :
English
ISSN :
1474-1784
Volume :
14
Issue :
8
Database :
MEDLINE
Journal :
Nature reviews. Drug discovery
Publication Type :
Academic Journal
Accession number :
26184493
Full Text :
https://doi.org/10.1038/nrd4696