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Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria.
- Source :
-
Microbiology spectrum [Microbiol Spectr] 2015 Jun; Vol. 3 (3). - Publication Year :
- 2015
-
Abstract
- Pathogenic bacteria must contend with immune systems that actively restrict the availability of nutrients and cofactors, and create a hostile growth environment. To deal with these hostile environments, pathogenic bacteria have evolved or acquired virulence determinants that aid in the acquisition of nutrients. This connection between pathogenesis and nutrition may explain why regulators of metabolism in nonpathogenic bacteria are used by pathogenic bacteria to regulate both metabolism and virulence. Such coordinated regulation is presumably advantageous because it conserves carbon and energy by aligning synthesis of virulence determinants with the nutritional environment. In Gram-positive bacterial pathogens, at least three metabolite-responsive global regulators, CcpA, CodY, and Rex, have been shown to coordinate the expression of metabolism and virulence genes. In this chapter, we discuss how environmental challenges alter metabolism, the regulators that respond to this altered metabolism, and how these regulators influence the host-pathogen interaction.
- Subjects :
- Animals
Bacterial Proteins genetics
Bacterial Proteins metabolism
Citric Acid Cycle genetics
Gene Expression Regulation, Bacterial
Glycolysis genetics
Gram-Positive Bacteria genetics
Gram-Positive Bacteria pathogenicity
Humans
Pentose Phosphate Pathway genetics
Virulence Factors genetics
Citric Acid Cycle physiology
Glycolysis physiology
Gram-Positive Bacteria metabolism
Host-Pathogen Interactions genetics
Pentose Phosphate Pathway physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2165-0497
- Volume :
- 3
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Microbiology spectrum
- Publication Type :
- Academic Journal
- Accession number :
- 26185086
- Full Text :
- https://doi.org/10.1128/microbiolspec.MBP-0004-2014