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Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Aug; Vol. 36 (8), pp. 5743-52. Date of Electronic Publication: 2015 Jul 19. - Publication Year :
- 2015
-
Abstract
- Prior research has demonstrated how the endoplasmic reticulum (ER) functions as a multifunctional organelle and as a well-orchestrated protein-folding unit. It consists of sensors which detect stress-induced unfolded/misfolded proteins and it is the place where protein folding is catalyzed with chaperones. During this folding process, an immaculate disulfide bond formation requires an oxidized environment provided by the ER. Protein folding and the generation of reactive oxygen species (ROS) as a protein oxidative byproduct in ER are crosslinked. An ER stress-induced response also mediates the expression of the apoptosis-associated gene C/EBP-homologous protein (CHOP) and death receptor 5 (DR5). ER stress induces the upregulation of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor and opening new horizons for therapeutic research. These findings can be used to maximize TRAIL-induced apoptosis in xenografted mice. This review summarizes the current understanding of the interplay between ER stress and ROS. We also discuss how damage-associated molecular patterns (DAMPs) function as modulators of immunogenic cell death and how natural products and drugs have shown potential in regulating ER stress and ROS in different cancer cell lines. Drugs as inducers and inhibitors of ROS modulation may respectively exert inducible and inhibitory effects on ER stress and unfolded protein response (UPR). Reconceptualization of the molecular crosstalk among ROS modulating effectors, ER stress, and DAMPs will lead to advances in anticancer therapy.
- Subjects :
- Animals
Humans
Mice
Neoplasms pathology
Neoplasms therapy
Oxidative Stress genetics
Protein Folding
Receptors, TNF-Related Apoptosis-Inducing Ligand genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand metabolism
TNF-Related Apoptosis-Inducing Ligand genetics
TNF-Related Apoptosis-Inducing Ligand metabolism
Transcription Factor CHOP genetics
Transcription Factor CHOP metabolism
Antineoplastic Agents therapeutic use
Endoplasmic Reticulum Stress genetics
Molecular Targeted Therapy
Neoplasms genetics
Reactive Oxygen Species metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 36
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26188905
- Full Text :
- https://doi.org/10.1007/s13277-015-3797-0