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Outcomes following Kidney transplantation in IgA nephropathy: a UNOS/OPTN analysis.
- Source :
-
Clinical transplantation [Clin Transplant] 2015 Oct; Vol. 29 (10), pp. 911-9. Date of Electronic Publication: 2015 Aug 24. - Publication Year :
- 2015
-
Abstract
- This study updates assessment of post-transplant outcomes in IgAN patients in the modern era of immunosuppression. Using UNOS/OPTN data, patients ≥18 yr of age with first kidney transplant (1/1/1999 to 12/31/2008) were analyzed. Multivariable Cox regression models and propensity score-based matching techniques were used to estimate hazard ratios (HRs) for death-censored allograft survival (DCGS) and patient survival in IgAN compared to non-IgAN. Results of multivariable regression were stratified by donor type (living vs. deceased). A total of 107, 747 recipients were included (4589 with IgAN and 103 158 with non-IgAN). Adjusted HR for DCGS showed no significant difference between IgAN and non-IgAN. IgAN had higher patient survival compared to non-IgAN (HR 0.54, 95% CI 0.47-0.62, p < 0.0001 for deceased donors; HR 0.42, 95% CI 0.33-0.54, p < 0.0001 for living donors). Propensity score-matched analysis was similar, with no significant difference in DCGS between matched groups and higher patient survival in IgAN patients compared to non-IgAN group (HR 0.54, 95% CI 0.47, 0.63; p-value <0.0001). IgAN patients with first kidney transplant have superior patient survival and similar graft survival compared to non-IgAN recipients. Results can be used in prognostication and informed decision-making about kidney transplantation in patients with IgAN.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Databases, Factual
Female
Follow-Up Studies
Glomerulonephritis, IGA mortality
Graft Survival
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Propensity Score
Proportional Hazards Models
Retrospective Studies
Transplantation, Homologous
Treatment Outcome
United States
Young Adult
Glomerulonephritis, IGA surgery
Kidney Transplantation mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 29
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 26190417
- Full Text :
- https://doi.org/10.1111/ctr.12594