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Health benefits of anthocyanins and molecular mechanisms: Update from recent decade.
- Source :
-
Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2017 May 24; Vol. 57 (8), pp. 1729-1741. - Publication Year :
- 2017
-
Abstract
- Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.
- Subjects :
- Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents pharmacology
Anti-Obesity Agents chemistry
Anti-Obesity Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Apoptosis
Autophagy
Cardiovascular Diseases prevention & control
Cell Cycle
Humans
Hypoglycemic Agents chemistry
Hypoglycemic Agents pharmacology
Neuroprotective Agents chemistry
Neuroprotective Agents pharmacology
Signal Transduction
Anthocyanins chemistry
Anthocyanins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1549-7852
- Volume :
- 57
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Critical reviews in food science and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 26192537
- Full Text :
- https://doi.org/10.1080/10408398.2015.1030064