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Elevated Plasma Soluble CD14 Levels Correlate with the Monocyte Response Status During Hantaan Virus Infection in Humans.
- Source :
-
Viral immunology [Viral Immunol] 2015 Oct; Vol. 28 (8), pp. 442-7. Date of Electronic Publication: 2015 Jul 21. - Publication Year :
- 2015
-
Abstract
- Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans. CD14, a pattern recognition receptor recognizing lipopolysaccharide, is highly expressed on monocytes and can be shed as soluble CD14 (sCD14) upon monocyte activation. To understand the role of sCD14 in HFRS, the sCD14 plasma concentrations from 45 HFRS patients were quantified, and the relationships between the plasma sCD14 level and the monocyte response status and clinical parameters were analyzed. The plasma sCD14 levels were significantly higher in the HFRS patients and they correlated with monocyte expansion and activation, which were characterized by increased blood monocyte counts, the proportion of CD14(++)CD16(+) intermediate monocytes, as well as elevated plasma tumor necrosis factor-α (TNF-α) and soluble CD163 (sCD163) levels. Additionally, the high plasma sCD14 levels positively correlated with white blood cell counts and blood urea nitrogen levels and negatively correlated with platelet counts in the HFRS patients. Taken together, our data indicate that elevated plasma sCD14 levels are associated with the monocyte response status during HTNV infection in humans.
- Subjects :
- Adolescent
Adult
Aged
Antigens, CD blood
Antigens, Differentiation, Myelomonocytic blood
Blood Urea Nitrogen
Female
Humans
Leukocyte Count
Male
Middle Aged
Platelet Count
Receptors, Cell Surface blood
Tumor Necrosis Factor-alpha blood
Young Adult
Hantaan virus immunology
Hemorrhagic Fever with Renal Syndrome pathology
Lipopolysaccharide Receptors blood
Monocytes immunology
Plasma chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8976
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Viral immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26196589
- Full Text :
- https://doi.org/10.1089/vim.2015.0040