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Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2016 Mar 15; Vol. 213 (6), pp. 904-14. Date of Electronic Publication: 2015 Jul 22. - Publication Year :
- 2016
-
Abstract
- Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.<br /> (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Animals
Antibodies, Viral
Callithrix
Cells, Cultured
Dipeptidyl Peptidase 4 genetics
Dipeptidyl Peptidase 4 metabolism
Gene Expression Regulation
Humans
Palatine Tonsil cytology
Severe acute respiratory syndrome-related coronavirus physiology
Spleen cytology
T-Lymphocytes physiology
Apoptosis physiology
Middle East Respiratory Syndrome Coronavirus physiology
T-Lymphocytes virology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 213
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26203058
- Full Text :
- https://doi.org/10.1093/infdis/jiv380