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Candida glabrata--unique features and challenges in the clinical management of invasive infections.
- Source :
-
Mycoses [Mycoses] 2015 Aug; Vol. 58 (8), pp. 445-50. - Publication Year :
- 2015
-
Abstract
- Candida glabrata is a pathogenic yeast with several unique biological features. This article provides an up-to-date review on current data and reasoning aspects of this clinically problematic organism. Haploidy, absence of pseudohyphae, facultative anaerobe growth of C. glabrata, as well as its intrinsically low susceptibility to azole antifungals require specific consideration in diagnosis and treatment approaches. As C. glabrata today represents a sizeable percentage of pathogens in candidaemia, the use of azole antifungals in upfront therapy of invasive yeast infections is discouraged by recent guidelines. While the selection of C. glabrata mutants with impaired susceptibility to echinocandins has been described, analyses of several clinical studies indicate an association of improved outcomes with the use of echinocandins as the primary treatment for invasive yeast infections with potential or documented involvement of C. glabrata.<br /> (© 2015 Blackwell Verlag GmbH.)
- Subjects :
- Azoles therapeutic use
Candida glabrata drug effects
Candida glabrata genetics
Candida glabrata physiology
Candidiasis, Invasive diagnosis
Candidiasis, Invasive epidemiology
Candidiasis, Invasive microbiology
Drug Resistance, Fungal
Echinocandins therapeutic use
Humans
Microbial Sensitivity Tests
Mutation
Antifungal Agents therapeutic use
Candida glabrata pathogenicity
Candidiasis, Invasive drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0507
- Volume :
- 58
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Mycoses
- Publication Type :
- Academic Journal
- Accession number :
- 26207423
- Full Text :
- https://doi.org/10.1111/myc.12348