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Increased IL-3 serum levels in chronic patients with schizophrenia: Associated with psychopathology.
- Source :
-
Psychiatry research [Psychiatry Res] 2015 Sep 30; Vol. 229 (1-2), pp. 225-9. Date of Electronic Publication: 2015 Jul 16. - Publication Year :
- 2015
-
Abstract
- Schizophrenia is associated with the inflammation-related pathways, including aberrant cytokines levels. In this study, we examined the association of serum IL-3 levels with psychopahological symtoms in chronic schizophrenia. Serum IL-3 levels were assessed in 42 patients diagnosed with schizophrenia and compared to 43 healthy control subjects matched for age and gender. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS), and serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). Our results showed that IL-3 levels were significantly increased in patients with chronic schizophrenia compared to healthy control subjects. Correlation analysis revealed a significant positive correlation between the IL-3 levels and the PANSS general subscore. Moreover, IL-3 levels were significantly positively correlated with depressive subscore. Our results suggested that IL-3 related pathway is associated with psychopathology of schizophrenia patients.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Chronic Disease
Depressive Disorder diagnosis
Depressive Disorder immunology
Depressive Disorder psychology
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Psychopathology
Schizophrenia diagnosis
Statistics as Topic
Interleukin-3 blood
Schizophrenia immunology
Schizophrenic Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7123
- Volume :
- 229
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 26208986
- Full Text :
- https://doi.org/10.1016/j.psychres.2015.07.029