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FTO Polymorphism rs9939609 Contributes to Weight Changes in Children With Celiac Disease on Gluten-Free Diet.
- Source :
-
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2015 Aug; Vol. 61 (2), pp. 220-3. - Publication Year :
- 2015
-
Abstract
- Objectives: Studies of adults and children with celiac disease have reported an increased risk of overweight during gluten-free diet (GFD). The fat mass and obesity-associated gene (FTO) variant rs9939609 has been associated with increased risk of developing obesity in children and adults.<br />Methods: In our study, we analyzed the effect of this variant on weight gain in a cohort of 280 children with celiac disease on GFD.<br />Results: We found that after a mean follow-up time of 3.0 years on GFD, FTO polymorphism influenced significantly the mean change in body mass index z score (P = 0.01).<br />Conclusions: We conclude that the FTO gene contributes to determine weight changes in children with celiac disease on GFD.
- Subjects :
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Body Mass Index
Celiac Disease physiopathology
Child
Child, Preschool
Female
Gene Frequency
Humans
Infant
Italy
Male
Obesity etiology
Overweight etiology
Retrospective Studies
Body Weight genetics
Celiac Disease diet therapy
Diet, Gluten-Free adverse effects
Polymorphism, Genetic genetics
Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4801
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 26222659
- Full Text :
- https://doi.org/10.1097/MPG.0000000000000724