Back to Search
Start Over
"Sudden Drop" in Blood Pressure is Associated With Recanalization After Thrombolysis.
- Source :
-
Medicine [Medicine (Baltimore)] 2015 Jul; Vol. 94 (30), pp. e1132. - Publication Year :
- 2015
-
Abstract
- We aim to investigate whether the phenomenon of "sudden drop" in blood pressure (BP) within the first 2 hours is associated with vessel recanalization.We retrospectively examined clinical and imaging data from a consecutive series of patients with stroke with large vessel occlusion treated with intravenous thrombolysis (IVT). BP was monitored every 15 minutes during the first 2 hours, then every 30 minutes for 6 hours, and then every hour for 16 hours.We observed the phenomenon of "sudden drop" in systolic BP (≥20 mm Hg) in 82 (50.9%) patients in the first 2 hours and vessel recanalization in 87 (54.0%) patients 24 hours after treatment. This phenomenon was independently associated with recanalization (odds ratio 2.100; 95% confidence interval: 1.085-4.062; P = 0.028) after adjusting for the history of atrial fibrillation, coronary heart disease, and hypertension.The phenomenon of "sudden drop" in systolic BP with 20 mm Hg or greater between 2 continuous measurements within the first 2 hours is associated with recanalization after IVT in patients with large vessel occlusion, especially for middle cerebral artery occlusion.
- Subjects :
- Acute Disease
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Hypotension physiopathology
Infarction, Middle Cerebral Artery diagnosis
Infarction, Middle Cerebral Artery physiopathology
Infusions, Intravenous
Magnetic Resonance Angiography
Male
Middle Aged
Retrospective Studies
Tomography, X-Ray Computed
Blood Pressure physiology
Cerebrovascular Circulation drug effects
Fibrinolytic Agents administration & dosage
Hypotension etiology
Infarction, Middle Cerebral Artery drug therapy
Thrombolytic Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 94
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26222844
- Full Text :
- https://doi.org/10.1097/MD.0000000000001132