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Neutrophil-to-lymphocyte ratio: an inflammation marker related to cardiovascular risk in children.
- Source :
-
Thrombosis and haemostasis [Thromb Haemost] 2015 Oct; Vol. 114 (4), pp. 727-34. Date of Electronic Publication: 2015 Jul 30. - Publication Year :
- 2015
-
Abstract
- Low-grade chronic inflammation plays a pathogenic role in cardiovascular disease. An increase in the ratio of circulating neutrophils to lymphocytes (N/L ratio) may serve as a marker of cardiovascular risk in adults. It was the study objective to study whether N/L ratio associates with vascular parameters in children. Subjects were 501 prepubertal and early pubertal Caucasian children (mean age 8.0 years; mean body mass index (BMI) Z-score 0.2 ± 0.9; 266 boys and 235 girls) recruited within an ongoing population-based study. The subjects were stratified into three groups according to age. Neutrophil, lymphocyte, BMI, waist circumference, systolic blood pressure (SBP) and carotid intima-media thickness (cIMT), assessed in all children. The N/L ratio, derived from the absolute neutrophil and lymphocyte counts. In children aged < 7 years (n=190, all prepubertal), no associations were observed between N/L ratio and either anthropometric or cardiovascular parameters. In children aged 7-9 years (n=171, 1.7% early pubertal), higher N/L ratio associated with higher BMI Z-score and waist circumference (p=0.008 to p < 0.0001). In children aged >9 years (n=140, 29.2% early pubertal), N/L ratio associated again with BMI Z-score and waist circumference and also positively with SBP and cIMT (all p=0.008 to p<0.0001). These associations remained significant in linear regression models following adjustment for possible confounding variables such as age, gender, fasting triglycerides, C-reactive protein and puberty (and for SBP and cIMT, adjustment also for BMI). In conclusion, our results provide the first evidence that a higher N/L ratio is associated with a less favourable cardiovascular profile in children and delineate the development of these associations from late childhood onwards.
- Subjects :
- Age Factors
Blood Pressure
Body Mass Index
Cardiovascular Diseases diagnosis
Cardiovascular Diseases ethnology
Cardiovascular Diseases physiopathology
Carotid Intima-Media Thickness
Child
Child, Preschool
Chronic Disease
Cross-Sectional Studies
Female
Humans
Inflammation diagnosis
Inflammation ethnology
Inflammation physiopathology
Linear Models
Lymphocyte Count
Male
Multivariate Analysis
Predictive Value of Tests
Prognosis
Puberty
Risk Assessment
Risk Factors
Spain epidemiology
Waist Circumference
White People
Cardiovascular Diseases immunology
Inflammation immunology
Lymphocytes immunology
Neutrophils immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2567-689X
- Volume :
- 114
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Thrombosis and haemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 26224329
- Full Text :
- https://doi.org/10.1160/TH15-01-0037