Back to Search Start Over

Neutrophil-to-lymphocyte ratio: an inflammation marker related to cardiovascular risk in children.

Authors :
Prats-Puig A
Gispert-Saüch M
Díaz-Roldán F
Carreras-Badosa G
Osiniri I
Planella-Colomer M
Mayol L
de Zegher F
Ibánez L
Bassols J
López-Bermejo A
Source :
Thrombosis and haemostasis [Thromb Haemost] 2015 Oct; Vol. 114 (4), pp. 727-34. Date of Electronic Publication: 2015 Jul 30.
Publication Year :
2015

Abstract

Low-grade chronic inflammation plays a pathogenic role in cardiovascular disease. An increase in the ratio of circulating neutrophils to lymphocytes (N/L ratio) may serve as a marker of cardiovascular risk in adults. It was the study objective to study whether N/L ratio associates with vascular parameters in children. Subjects were 501 prepubertal and early pubertal Caucasian children (mean age 8.0 years; mean body mass index (BMI) Z-score 0.2 ± 0.9; 266 boys and 235 girls) recruited within an ongoing population-based study. The subjects were stratified into three groups according to age. Neutrophil, lymphocyte, BMI, waist circumference, systolic blood pressure (SBP) and carotid intima-media thickness (cIMT), assessed in all children. The N/L ratio, derived from the absolute neutrophil and lymphocyte counts. In children aged < 7 years (n=190, all prepubertal), no associations were observed between N/L ratio and either anthropometric or cardiovascular parameters. In children aged 7-9 years (n=171, 1.7% early pubertal), higher N/L ratio associated with higher BMI Z-score and waist circumference (p=0.008 to p < 0.0001). In children aged >9 years (n=140, 29.2% early pubertal), N/L ratio associated again with BMI Z-score and waist circumference and also positively with SBP and cIMT (all p=0.008 to p<0.0001). These associations remained significant in linear regression models following adjustment for possible confounding variables such as age, gender, fasting triglycerides, C-reactive protein and puberty (and for SBP and cIMT, adjustment also for BMI). In conclusion, our results provide the first evidence that a higher N/L ratio is associated with a less favourable cardiovascular profile in children and delineate the development of these associations from late childhood onwards.

Details

Language :
English
ISSN :
2567-689X
Volume :
114
Issue :
4
Database :
MEDLINE
Journal :
Thrombosis and haemostasis
Publication Type :
Academic Journal
Accession number :
26224329
Full Text :
https://doi.org/10.1160/TH15-01-0037