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Endothelial progenitor cells support tumour growth and metastatisation: implications for the resistance to anti-angiogenic therapy.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Sep; Vol. 36 (9), pp. 6603-14. Date of Electronic Publication: 2015 Aug 02. - Publication Year :
- 2015
-
Abstract
- Endothelial progenitor cells (EPCs) have recently been shown to promote the angiogenic switch in solid neoplasms, thereby promoting tumour growth and metastatisation. The genetic suppression of EPC mobilization from bone marrow prevents tumour development and colonization of remote organs. Therefore, it has been assumed that anti-angiogenic treatments, which target vascular endothelial growth factor (VEGF) signalling in both normal endothelial cells and EPCs, could interfere with EPC activation in cancer patients. Our recent data, however, show that VEGF fails to stimulate tumour endothelial colony-forming cells (ECFCs), i.e. the only EPC subtype truly belonging to the endothelial lineage. The present article will survey current evidence about EPC involvement in the angiogenic switch: we will focus on the controversy about EPC definition and on the debate around their actual incorporation into tumour neovessels. We will then discuss how ECFC insensitivity to VEGF stimulation in cancer patients could underpin their well-known resistance to anti-VEGF therapies.
- Subjects :
- Calcium metabolism
Drug Resistance, Neoplasm genetics
Endothelial Progenitor Cells metabolism
Gene Expression Regulation, Neoplastic drug effects
Humans
Neoplasms drug therapy
Neoplasms pathology
Neovascularization, Pathologic drug therapy
Neovascularization, Pathologic pathology
Signal Transduction drug effects
Vascular Endothelial Growth Factor A antagonists & inhibitors
Vascular Endothelial Growth Factor A genetics
Endothelial Progenitor Cells pathology
Neoplasms genetics
Neovascularization, Pathologic genetics
Vascular Endothelial Growth Factor A biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 36
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26232913
- Full Text :
- https://doi.org/10.1007/s13277-015-3823-2