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The search for nucleoside/nucleotide analog inhibitors of dengue virus.
- Source :
-
Antiviral research [Antiviral Res] 2015 Oct; Vol. 122, pp. 12-9. Date of Electronic Publication: 2015 Aug 01. - Publication Year :
- 2015
-
Abstract
- Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Antiviral Agents chemistry
Antiviral Agents metabolism
Dengue virology
Dengue Virus metabolism
Drug Discovery
Humans
Nucleosides chemistry
Nucleotides chemistry
Virus Replication drug effects
Antiviral Agents pharmacology
Dengue drug therapy
Dengue Virus drug effects
Nucleosides pharmacology
Nucleotides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9096
- Volume :
- 122
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 26241002
- Full Text :
- https://doi.org/10.1016/j.antiviral.2015.07.010