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One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Sep 14; Vol. 13 (34), pp. 8993-5. Date of Electronic Publication: 2015 Aug 05. - Publication Year :
- 2015
-
Abstract
- A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 13
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26243009
- Full Text :
- https://doi.org/10.1039/c5ob01462j