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One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes.

Authors :
Maslivetc VA
Rubina M
Rubin M
Source :
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Sep 14; Vol. 13 (34), pp. 8993-5. Date of Electronic Publication: 2015 Aug 05.
Publication Year :
2015

Abstract

A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.

Details

Language :
English
ISSN :
1477-0539
Volume :
13
Issue :
34
Database :
MEDLINE
Journal :
Organic & biomolecular chemistry
Publication Type :
Academic Journal
Accession number :
26243009
Full Text :
https://doi.org/10.1039/c5ob01462j