Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis.

Authors :: Cabibbe AM
Miotto P
Moure R
Alcaide F
Feuerriegel S
Pozzi G
Nikolayevskyy V
Drobniewski F
Niemann S
Reither K
Cirillo DM
Source :: Journal of clinical microbiology [J Clin Microbiol] 2015 Dec; Vol. 53 (12), pp. 3876-80. Date of Electronic Publication: 2015 Aug 05.
Publication Year :: 2015
Abstract: We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Subjects :: Antitubercular Agents pharmacology
Drug Resistance, Multiple, Bacterial
Humans
Isoniazid pharmacology
Mycobacterium tuberculosis drug effects
Rifampin pharmacology
Lab-On-A-Chip Devices
Molecular Diagnostic Techniques methods
Tuberculosis, Multidrug-Resistant diagnosis

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