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Combination of Azathioprine and Aminosalicylate Treatment Prevent Risk of Cardiovascular Disease in Women with Ulcerative Colitis by Reducing Inflammation.
- Source :
-
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2015 Aug 07; Vol. 21, pp. 2305-15. Date of Electronic Publication: 2015 Aug 07. - Publication Year :
- 2015
-
Abstract
- Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with involvement of the immune system. Chronic inflammatory diseases have been associated with increased risk of cardiovascular disease (CVD) but few studies have assessed this risk in patients with UC and the influence of drug treatment. Thus, we evaluated the risk of development of CVD in women with UC in clinical remission, considering the drug treatment.<br />Material and Methods: Twenty-one women with UC participated in this study: 12 used aminosalicylates (ASA group) and 9 used azathioprine added to aminosalicylates (AZA+ASA group). The healthy control group was matched for age. We evaluated blood pressure, body composition, and biochemical and immunological parameters.<br />Results: Compared to the respective control group, the UC groups showed expansion of body fat and less lean body mass. Blood pressure, pro-inflammatory cytokines, nitric oxide, C reactive protein, erythrocyte sedimentation rate (ESR), and anti-oxidized LDL antibodies were higher in UC groups. Only AZA+ASA group showed increased anti-inflammatory cytokines (IL-10 and TGF-β). Framingham scores showed higher risk of CVD in UC groups. UC groups were compared and women treated with azathioprine showed reduction of total protein, globulin, ESR, and lymphocytes, with increased IL-6, TNF, IL-10, and TGF-β.<br />Conclusions: Our data suggest that women with UC in clinical remission have a higher risk for development of atherosclerosis and CVD when compared to the control group, while women treated with azathioprine seem more protected than those treated only with aminosalicylates, due to better regulation of the inflammatory process.
- Subjects :
- Adult
Biomarkers blood
Cardiovascular Diseases etiology
Case-Control Studies
Colitis, Ulcerative blood
Colitis, Ulcerative complications
Cytokines blood
Drug Therapy, Combination
Female
Humans
Immunosuppressive Agents administration & dosage
Inflammation etiology
Inflammation Mediators blood
Lipids blood
Male
Middle Aged
Remission Induction
Risk Factors
Young Adult
Aminosalicylic Acid administration & dosage
Azathioprine administration & dosage
Cardiovascular Diseases prevention & control
Colitis, Ulcerative drug therapy
Inflammation prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1643-3750
- Volume :
- 21
- Database :
- MEDLINE
- Journal :
- Medical science monitor : international medical journal of experimental and clinical research
- Publication Type :
- Academic Journal
- Accession number :
- 26252649
- Full Text :
- https://doi.org/10.12659/MSM.893865