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Highly sensitive and selective uric acid biosensor based on a three-dimensional graphene foam/indium tin oxide glass electrode.
- Source :
-
Analytical biochemistry [Anal Biochem] 2015 Nov 01; Vol. 488, pp. 22-7. Date of Electronic Publication: 2015 Aug 06. - Publication Year :
- 2015
-
Abstract
- A three-dimensional (3D) continuous and interconnected network graphene foam (GF) was synthesized by chemical vapor deposition using nickel foam as a template. The morphologies of the GF were observed by scanning electron microscopy. X-ray diffraction and Raman spectroscopy were used to investigate the structure of GF. The graphene with few layers and defect free was closely coated on the backbone of the 3D nickel foam. After etching nickel, the GF was transferred onto indium tin oxide (ITO) glass, which acted as an electrode to detect uric acid using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The GF/ITO electrode showed a high sensitivity for the detection of uric acid: approximately 9.44 mA mM(-1) in the range of 25 nM-0.1 μM and 1.85 mA mM(-1) in the range of 0.1-60 μM. The limit of detection of GF/ITO electrode for uric acid is 3 nM. The GF/ITO electrode also showed a high selectivity for the detection of uric acid in the presence of ascorbic acid. This electrode will have a wide range of potential application prospects in electrochemical detection.<br /> (Copyright © 2015. Published by Elsevier Inc.)
- Subjects :
- Antioxidants chemistry
Ascorbic Acid chemistry
Biosensing Techniques
China
Electrochemical Techniques
Electrodes
Graphite chemistry
Humans
Imaging, Three-Dimensional
Indium chemistry
Limit of Detection
Microscopy, Electron, Scanning
Spectrum Analysis, Raman
Tin Compounds chemistry
Uric Acid blood
Uric Acid urine
X-Ray Diffraction
Uric Acid analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0309
- Volume :
- 488
- Database :
- MEDLINE
- Journal :
- Analytical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26254685
- Full Text :
- https://doi.org/10.1016/j.ab.2015.07.007