Synthesis of 2-[(18)F]Fluoro-2-deoxyisosorbide 5-mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET).

Authors :: Santschi N
Wagner S
Daniliuc C
Hermann S
Schäfers M
Gilmour R
Source :: ChemMedChem [ChemMedChem] 2015 Oct; Vol. 10 (10), pp. 1724-32. Date of Electronic Publication: 2015 Aug 12.
Publication Year :: 2015
Abstract: Herein we disclose the synthesis of 2-fluoro-2-deoxyisosorbide 5-mononitrate (2F-IS-5MN), a fluorinated analogue of the commonly prescribed vasodilator isosorbide 5-mononitrate (IS-5MN). X-ray structural data for IS-5MN and its C2-epimeric congener IM-5MN are presented together with structural data for 2F-IS-5MN. Radioisotope labeling of 2F-IS-5MN has, for the first time, allowed observation of the in vivo biodistribution of this organic nitrate by means of dynamic positron emission tomography (PET) in wild-type mice.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Isosorbide analysis
Isosorbide chemical synthesis
Isosorbide chemistry
Isosorbide pharmacokinetics
Male
Mice
Mice, Inbred C57BL
Models, Molecular
Molecular Structure
Nitrates chemical synthesis
Nitrates chemistry
Tissue Distribution
Fluorine Radioisotopes chemistry
Isosorbide analogs & derivatives
Nitrates analysis
Nitrates pharmacokinetics
Positron-Emission Tomography

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