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Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2015 Aug; Vol. 26 (8), pp. 225. Date of Electronic Publication: 2015 Aug 19. - Publication Year :
- 2015
-
Abstract
- PEG-PCL-PEG (PECE) hydrogel for intracameral injection as a sustained delivery system can get a stable release of the medication and achieve an effective local concentration. The injectable PECE hydrogel is thermosensitive nano-material which is flowing sol at low temperature and can shift to nonflowing gel at body temperature. This study evaluated the intracameral injection of bevacizumab combined with a PECE hydrogel drug release system on postoperative scarring and bleb survival after experimental glaucoma filtration surgery. The best result was achieved in the bevacizumab loaded PECE hydrogels group, which presented the lowest IOP values after surgery. And the blebs were significantly more persistent in this group. Histology, Massion trichrome staining and immunohistochemistry further demonstrated that glaucoma filtration surgery in combination with bevacizumab loaded PECE hydrogel resulted in good bleb survival due to scar formation inhibition. In conclusions, this study demonstrated that bevacizumab-loaded PECE hydrogel for intracameral injection as a sustained delivery system provide a great opportunity to increase the therapeutic efficacy of glaucoma filtration surgery.
- Subjects :
- Actins metabolism
Animals
Cicatrix prevention & control
Disease Models, Animal
Glaucoma physiopathology
Hydrogels
Postoperative Complications prevention & control
Rabbits
Vascular Endothelial Growth Factor A antagonists & inhibitors
Angiogenesis Inhibitors administration & dosage
Bevacizumab administration & dosage
Drug Delivery Systems
Filtering Surgery adverse effects
Glaucoma drug therapy
Glaucoma surgery
Intraocular Pressure drug effects
Polyesters
Polyethylene Glycols
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26286760
- Full Text :
- https://doi.org/10.1007/s10856-015-5556-6