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Rift Valley fever virus: A review of diagnosis and vaccination, and implications for emergence in Europe.

Authors :
Mansfield KL
Banyard AC
McElhinney L
Johnson N
Horton DL
Hernández-Triana LM
Fooks AR
Source :
Vaccine [Vaccine] 2015 Oct 13; Vol. 33 (42), pp. 5520-5531. Date of Electronic Publication: 2015 Aug 19.
Publication Year :
2015

Abstract

Rift Valley fever virus (RVFV) is a mosquito-borne virus, and is the causative agent of Rift Valley fever (RVF), a zoonotic disease characterised by an increased incidence of abortion or foetal malformation in ruminants. Infection in humans can also lead to clinical manifestations that in severe cases cause encephalitis or haemorrhagic fever. The virus is endemic throughout much of the African continent. However, the emergence of RVFV in the Middle East, northern Egypt and the Comoros Archipelago has highlighted that the geographical range of RVFV may be increasing, and has led to the concern that an incursion into Europe may occur. At present, there is a limited range of veterinary vaccines available for use in endemic areas, and there is no licensed human vaccine. In this review, the methods available for diagnosis of RVFV infection, the current status of vaccine development and possible implications for RVFV emergence in Europe, are discussed.<br /> (Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1873-2518
Volume :
33
Issue :
42
Database :
MEDLINE
Journal :
Vaccine
Publication Type :
Academic Journal
Accession number :
26296499
Full Text :
https://doi.org/10.1016/j.vaccine.2015.08.020