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Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.
- Source :
-
Neuron [Neuron] 2015 Sep 02; Vol. 87 (5), pp. 999-1007. Date of Electronic Publication: 2015 Aug 20. - Publication Year :
- 2015
-
Abstract
- The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed while unrelated interneurons can be closely clustered. These data suggest that migratory mechanisms related to the clustering of interneurons occur largely independent of their clonal origin.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cell Lineage
Cells, Cultured
Cerebral Cortex cytology
Embryo, Mammalian
Green Fluorescent Proteins genetics
Green Fluorescent Proteins metabolism
In Vitro Techniques
Laser Capture Microdissection
Mice
Nerve Tissue Proteins metabolism
Neural Stem Cells classification
Organ Culture Techniques
Telencephalon embryology
Transduction, Genetic
Cell Movement physiology
Interneurons physiology
Nerve Net physiology
Neural Inhibition
Neural Stem Cells physiology
Telencephalon cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 87
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 26299474
- Full Text :
- https://doi.org/10.1016/j.neuron.2015.07.030