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4EBP1 Is Dephosphorylated by Respiratory Syncytial Virus Infection.
- Source :
-
Intervirology [Intervirology] 2015; Vol. 58 (4), pp. 205-8. Date of Electronic Publication: 2015 Aug 21. - Publication Year :
- 2015
-
Abstract
- Respiratory syncytial virus (RSV) requires protein biosynthesis machinery to generate progeny. There is evidence that RSV might alter some translation components since stress granules are formed in their host cells. Consistent with these observations, we found that RSV induces dephosphorylation of 4EBP1 (eIF4E-binding protein), an important cellular translation factor. Our results show no correlation between the 4EBP1 dephosphorylation time and the decrease in the global rate of protein synthesis. Interestingly, treatment with rapamycin stimulates virus generation. The results suggest that RSV is a virus that still contains unknown mechanisms involved in the translation of their mRNAs through the alteration or modification of some translation factors, such as 4EBP1, possibly to favor its replicative cycle.<br /> (© 2015 S. Karger AG, Basel.)
- Subjects :
- Cell Cycle Proteins
Cell Line
Epithelial Cells virology
Humans
Phosphorylation
RNA, Messenger genetics
Sirolimus adverse effects
Sirolimus metabolism
Sirolimus pharmacology
Virus Replication drug effects
Adaptor Proteins, Signal Transducing metabolism
Phosphoproteins metabolism
Protein Biosynthesis
Respiratory Syncytial Virus, Human physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0100
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Intervirology
- Publication Type :
- Academic Journal
- Accession number :
- 26305094
- Full Text :
- https://doi.org/10.1159/000435774