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Maternal-infant biomarkers of prenatal exposure to arsenic and manganese.
- Source :
-
Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2015 Nov-Dec; Vol. 25 (6), pp. 639-48. Date of Electronic Publication: 2015 Aug 26. - Publication Year :
- 2015
-
Abstract
- Because arsenic (As) and manganese (Mn) are able to pass the placenta, infants among exposed populations may be exposed to considerable levels in utero. The main objective of this paper is to evaluate infant toenails, hair, and cord blood as biomarkers of prenatal exposure to As and Mn and determine the relationship between maternal and infant As and Mn concentrations in these biomarkers. Of the 1196 pregnant women in Bangladesh who were monitored throughout pregnancy until 1 month post-partum and completed all study visits, we included 711 mother-infant pairs who had at least one maternal and one infant biomarker of exposure available for analysis. Toenail and hair samples were collected from the women during the first trimester and 1 month post-partum and from the infants at the age of 1 month. Cord blood was collected at the time of delivery. Maternal toenail concentrations were correlated with infant toenail concentrations for As and Mn (n=258, r=0.52, 95% CI: 0.43-0.60, P<0.0001 and r=0.39, 95% CI: 0.28-0.49, P<0.0001), respectively. Similarly, maternal hair concentrations were correlated with infant hair As (n=685, r=0.61, 95% CI: 0.56-0.65, P<0.0001) and infant hair Mn (n=686, r=0.21, 95% CI: 0.14-0.28, P<0.0001). Cord blood As was correlated with infant toenail and hair As, although cord blood Mn was only correlated with infant toenail. Toenails and cord blood appear to be valid biomarkers of maternal-fetal transfer of As and Mn, whereas hair may not be a suitable biomarker for in utero exposure to Mn.
- Subjects :
- Arsenic blood
Bangladesh epidemiology
Biomarkers
Environmental Exposure
Female
Humans
Infant, Newborn
Male
Manganese blood
Pregnancy
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects metabolism
Prospective Studies
Young Adult
Arsenic analysis
Fetal Blood chemistry
Hair chemistry
Manganese analysis
Nails chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1559-064X
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of exposure science & environmental epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 26306926
- Full Text :
- https://doi.org/10.1038/jes.2015.45