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Genome-wide association study of prostate cancer-specific survival.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2015 Nov; Vol. 24 (11), pp. 1796-800. Date of Electronic Publication: 2015 Aug 25. - Publication Year :
- 2015
-
Abstract
- Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.<br />Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).<br />Results: We observed no significant association between genetic variants and prostate cancer survival.<br />Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study.<br />Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.<br /> (©2015 American Association for Cancer Research.)
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 24
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26307654
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-15-0543