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Therapeutic Ultrasound Contrast Agents for the Enhancement of Tumor Diagnosis and Tumor Therapy.
- Source :
-
Journal of biomedical nanotechnology [J Biomed Nanotechnol] 2015 Jul; Vol. 11 (7), pp. 1183-92. - Publication Year :
- 2015
-
Abstract
- The functionality of ultrasound in early cancer detection is limited because of its relatively low contrast resolution. Because it has a high degree of echogenicity, a microbubble contrast agent is often used to overcome this intrinsic limitation of imaging at low-contrast resolution. A targeted and drug-loaded microbubble contrast agent for simultaneous diagnosis and therapy has recently been investigated. However, no optimized theragnosis ultrasound microbubbles have been developed. Paclitaxel (PTX)-encapsulating human serum albumin nanoparticles (PTX-HSA-NPs) were conjugated onto an ultrasound microbubbles (PTX-HSA-NPs-MBs) fabricated in the laboratory to result in a narrow size distribution (1.7 ± 0.7 μm) and an optimal resonance frequency of 3 MHz. After intravenous injection of HSA-NPs-MBs, echogenicity in the tumor xenografted with breast cancer MCF-7 cells was significantly enhanced, showing the possibility of early cancer diagnosis. Mice injected with PTX-HSA-NPs-MBs showed higher survival rates in comparison with control groups, demonstrating the possibility of theragnosis. In the present study, the conjugation of PTX-HSA-NPs onto the ultrasound microbubbles simultaneously provided (1) enhanced ultrasound signal generation, (2) sufficient drug-loading capacity, (3) ability to deliver drugs to a preferred tumor site, and (4) increased stability in blood circulation.
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic administration & dosage
Antineoplastic Agents, Phytogenic chemistry
Apoptosis drug effects
Cell Survival drug effects
Contrast Media
Humans
Image Enhancement methods
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Nanocapsules chemistry
Treatment Outcome
Microbubbles therapeutic use
Nanocapsules therapeutic use
Paclitaxel administration & dosage
Ultrasonography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1550-7033
- Volume :
- 11
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of biomedical nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 26307841
- Full Text :
- https://doi.org/10.1166/jbn.2015.2056