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Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe(3+) in Cancer Stem Cells.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2015 Nov 04; Vol. 7 (43), pp. 23958-66. Date of Electronic Publication: 2015 Oct 26. - Publication Year :
- 2015
-
Abstract
- A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe(3+) detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 μM are demonstrated as a Fe(3+) turn-on fluorescent nanosensor in cancer stem cells. Fe(3+) binding to such GQDs (RBD-GQDs-Fe(3+)) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
- Subjects :
- Apoptosis
Biocompatible Materials chemistry
Biomarkers, Tumor metabolism
Cell Differentiation
Cell Lineage
Cell Proliferation
Cell Survival
Drug Delivery Systems
Electrochemistry methods
HeLa Cells
Humans
Microscopy, Confocal
Microscopy, Electron, Transmission
Neoplastic Stem Cells metabolism
Pancreatic Neoplasms pathology
Photochemistry
Solubility
Water chemistry
Graphite chemistry
Iron chemistry
Neoplastic Stem Cells cytology
Quantum Dots
Rhodamines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 7
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 26317667
- Full Text :
- https://doi.org/10.1021/acsami.5b06523