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[Disorders of cardiac contractile function in ischemic shock; the protective effect of antioxidants and liposomes made from egg phospholipids].
- Source :
-
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1989 Dec; Vol. 108 (12), pp. 660-3. - Publication Year :
- 1989
-
Abstract
- Experiments were made on Wistar rats with 6h tourniqueting of the hind limbs to study animal survival rate, myocardial contractile function and protective action of antioxidants and egg phospholipid liposomes during ischemic shock. It has been shown that reperfusion of the limbs leads to a high animal lethality, make lower myocardial contractile function and coronary flow of the hearts isolated from rats following a 6h reperfusion of the limbs. Well-known antioxidant butylated hydroxytoluene and a new antioxidant tetramethylpiperidine derivative bring animal lethality down and improve coronary flow and contractile function of the isolated heart. Phospholipid liposomes increase survival rate moderately but have no any effect on the heart contractile function. It has been deduced that lipid peroxidation takes part in the disturbance of heart contractile function and genesis of the death within ischemic shock.
- Subjects :
- Animals
Coronary Disease complications
Coronary Disease drug therapy
Coronary Disease mortality
Drug Carriers
Drug Evaluation, Preclinical
Female
Lipid Peroxidation drug effects
Lipid Peroxidation physiology
Liposomes
Myocardial Contraction drug effects
Rats
Rats, Inbred Strains
Shock, Cardiogenic drug therapy
Shock, Cardiogenic etiology
Shock, Cardiogenic mortality
Time Factors
Antioxidants therapeutic use
Coronary Disease physiopathology
Myocardial Contraction physiology
Phospholipids administration & dosage
Shock, Cardiogenic physiopathology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0365-9615
- Volume :
- 108
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biulleten' eksperimental'noi biologii i meditsiny
- Publication Type :
- Academic Journal
- Accession number :
- 2634433