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Congenital Type III von Willebrand's disease unmasked by hypothyroidism in a Shetland sheepdog.
- Source :
-
The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 2015 Sep; Vol. 56 (9), pp. 937-41. - Publication Year :
- 2015
-
Abstract
- A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand's disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed onset of disease and the reversible FVIII deficiency that was corrected with levothyroxine therapy, support a role for hypothyroidism in the pathogenesis of this dog's sudden bleeding tendency as has been seen with hypothyroidism in humans.
- Subjects :
- Animals
Dog Diseases etiology
Dog Diseases pathology
Dogs
Epistaxis etiology
Epistaxis veterinary
Factor VIII
Female
Hypothyroidism complications
Hypothyroidism drug therapy
Thyroxine therapeutic use
von Willebrand Disease, Type 3 complications
von Willebrand Disease, Type 3 diagnosis
von Willebrand Disease, Type 3 pathology
Dog Diseases diagnosis
Hypothyroidism veterinary
von Willebrand Disease, Type 3 veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5286
- Volume :
- 56
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Canadian veterinary journal = La revue veterinaire canadienne
- Publication Type :
- Academic Journal
- Accession number :
- 26347307