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Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease.
- Source :
-
Behavioural brain research [Behav Brain Res] 2016 Jan 01; Vol. 296, pp. 109-117. Date of Electronic Publication: 2015 Sep 07. - Publication Year :
- 2016
-
Abstract
- The pathologies of Alzheimer's disease (AD) is associated with soluble beta-amyloid (Aβ) oligomers, neuroinflammation and oxidative stress. Decreasing the levels of Aβ oligomer, glial activation and oxidative stress are potential therapeutic approaches for AD treatment. We previously found alpha-tocopherol quinine (α-TQ) inhibited Aβ aggregation and cytotoxicity, decreased the release of inflammatory cytokines and reactive oxygen species (ROS) in vitro. However, whether α-TQ ameliorates memory deficits and other neuropathologies in mice or patients with AD remains unknown. In this study, we reported that orally administered α-TQ ameliorated memory impairment in APPswe/PS1dE9 transgenic mice, decreased oxidative stress and the levels of Aβ oligomer in the brains of mice, prevented the production of inducible nitric oxide synthase and inflammatory mediators, such as interleukin-6 and interleukin-1β, and inhibited microglial activation by inhibiting NF-κB signaling pathway. These findings suggest that α-TQ has potential therapeutic value for AD treatment.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Amyloid beta-Peptides
Animals
Antioxidants administration & dosage
Behavior, Animal drug effects
Disease Models, Animal
Interleukins metabolism
Mice
Mice, Transgenic
Microglia drug effects
Signal Transduction drug effects
Vitamin E administration & dosage
Vitamin E pharmacology
Alzheimer Disease drug therapy
Antioxidants pharmacology
Brain drug effects
Inflammation drug therapy
Memory Disorders drug therapy
NF-kappa B drug effects
Oxidative Stress drug effects
Spatial Memory drug effects
Vitamin E analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 296
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 26358659
- Full Text :
- https://doi.org/10.1016/j.bbr.2015.09.003