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Increased risk of male cancer and identification of a potential prostate cancer cluster region in BRCA2.
- Source :
-
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2016; Vol. 55 (1), pp. 38-44. Date of Electronic Publication: 2015 Sep 11. - Publication Year :
- 2016
-
Abstract
- Background: The risk of cancer in men from BRCA1 and BRCA2 families is relevant to define to motivate genetic testing and optimize recommendations for surveillance.<br />Material and Methods: We assessed the risk of cancer in male mutation carriers and their first-degree relatives in 290 BRCA1 and BRCA2 families with comparison to matched controls with the aim to motivate genetic testing and optimize recommendations for surveillance.<br />Results: Mutation carriers in BRCA1 families were not at increased risk of cancer, whereas mutation carriers in BRCA2 families were at increased risk of male breast cancer and prostate cancer with cumulative risks of 12.5% and 18.8%, respectively. Breast cancer developed at a mean age of 59 years, typically as ER/PR positive ductal carcinomas. Prostate cancer developed at a mean age of 68 years, with Gleason scores ≥ 8 in 40% of the tumors. The hazard ratio for BRCA2-associated prostate cancer was 3.7 (p < 0.001) in mutation carriers and 3.1 (p = 0.001) in first-degree relatives. Of the 37 prostate cancers, 19 were linked to four BRCA2 mutations within a region defined by c.6373-c.6492. Individuals with mutations herein had a HR of 3.7 for prostate cancer compared to individuals with mutations outside of this region.<br />Conclusions: Male mutation carriers and first-degree relatives in BRCA2 families are at an increased risk of breast cancer and prostate cancer with a potential prostate cancer cluster region within exon 11 of BRCA2.
- Subjects :
- Age Factors
Aged
Breast Neoplasms, Male epidemiology
Denmark epidemiology
Family
Genetic Predisposition to Disease
Heterozygote
Humans
Male
Middle Aged
Neoplasm Grading
Prostatic Neoplasms epidemiology
Risk
Breast Neoplasms, Male genetics
Genes, BRCA1
Genes, BRCA2
Mutation
Prostatic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1651-226X
- Volume :
- 55
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta oncologica (Stockholm, Sweden)
- Publication Type :
- Academic Journal
- Accession number :
- 26360800
- Full Text :
- https://doi.org/10.3109/0284186X.2015.1067714