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miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis.
- Source :
-
Chinese journal of cancer [Chin J Cancer] 2015 Sep 14; Vol. 34 (11), pp. 485-7. Date of Electronic Publication: 2015 Sep 14. - Publication Year :
- 2015
-
Abstract
- Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of miR-506 in an orthotopic ovarian cancer mouse model significantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, miR-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of miR-506.
Details
- Language :
- English
- ISSN :
- 1000-467X
- Volume :
- 34
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Chinese journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 26369335
- Full Text :
- https://doi.org/10.1186/s40880-015-0049-z