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A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Dec 14; Vol. 13 (46), pp. 11208-19. Date of Electronic Publication: 2015 Sep 18. - Publication Year :
- 2015
-
Abstract
- d-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.
- Subjects :
- Alkylation
Anticoagulants chemical synthesis
Crystallography, X-Ray
Disaccharides chemical synthesis
Glucosamine chemical synthesis
Glycosaminoglycans chemical synthesis
Heparin chemical synthesis
Heparin, Low-Molecular-Weight chemical synthesis
Models, Molecular
Oligosaccharides chemical synthesis
Anticoagulants chemistry
Disaccharides chemistry
Glucosamine analogs & derivatives
Glycosaminoglycans chemistry
Heparin analogs & derivatives
Heparin, Low-Molecular-Weight analogs & derivatives
Oligosaccharides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 13
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26381107
- Full Text :
- https://doi.org/10.1039/c5ob01706h