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Micafungin Elicits an Immunomodulatory Effect in Galleria mellonella and Mice.
- Source :
-
Mycopathologia [Mycopathologia] 2016 Feb; Vol. 181 (1-2), pp. 17-25. Date of Electronic Publication: 2015 Sep 18. - Publication Year :
- 2016
-
Abstract
- The echinocandin family of drugs is well characterized for antifungal function that inhibits β-D-glucan synthesis. The aim of this work was to study whether micafungin, a member of the echinocandin family, elicits additional activities that prime the host's immune response. We found that in a Galleria mellonella model, prophylactic treatment with micafungin extended the life of Staphylococcus aureus-infected larvae (a pathogen to which the drug demonstrates no direct antimicrobial activity) compared to insects that did not receive micafungin (P < 0.05). The inhibition of pathogens in the G. mellonella infection model was characterized by a 2.43-fold increase in hemocyte density, compared to larvae inoculated with PBS. In a murine model where animals were provided micafungin prophylaxis 3 days prior to macrophage collection, macrophages were found associated with an average 0.9 more fungal cells per macrophage as compared to saline-treated animals. Interestingly, micafungin-stimulated macrophages killed 11.6 ± 6.2 % of fungal cells compared to 3.8 ± 2.4 % of macrophages from saline-treated animals. The prophylactic provision of micafungin prior to Candida albicans infection was characterized by an increase in the proinflammatory cytokines CXCL13 and SPP1 by 11- and 6.9-fold, respectively. In conclusion, micafungin demonstrated the ability to stimulate phagocytic cells and promote an immune response that can inhibit microbial infections.
- Subjects :
- Animals
Candida albicans immunology
Candida albicans physiology
Disease Models, Animal
Lepidoptera
Macrophages immunology
Macrophages microbiology
Micafungin
Mice
Microbial Viability
Staphylococcal Infections drug therapy
Survival Analysis
Treatment Outcome
Echinocandins administration & dosage
Echinocandins pharmacology
Immunologic Factors administration & dosage
Immunologic Factors pharmacology
Lipopeptides administration & dosage
Lipopeptides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0832
- Volume :
- 181
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Mycopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 26384671
- Full Text :
- https://doi.org/10.1007/s11046-015-9940-z