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Effect of beta-blocker therapy on heart rate response in patients with hypertension and newly diagnosed untreated obstructive sleep apnea syndrome.
- Source :
-
International journal of cardiology [Int J Cardiol] 2016 Jan 01; Vol. 202, pp. 67-72. Date of Electronic Publication: 2015 Aug 21. - Publication Year :
- 2016
-
Abstract
- Background: Beta1-receptor antagonists (BBs) are commonly administered in the treatment of cardiovascular disease (CVD). The reported benefits of BB use in CVD patients with concomitant obstructive sleep apnea (OSA) may be limited by their impact on apnea-induced bradycardias. Therefore the aim of the study was to test the influence of BBs on periapneic heart rate (HR) fluctuations in hypertensive patients with newly-detected and untreated OSA.<br />Methods: We studied 88 hypertensive patients (56 on BBs and 32 BB naive) with newly-diagnosed moderate-to-severe OSA who were free of major pulmonary comorbidities and did not require antiarrhythmic therapy. ECGs recorded during sleep were investigated for heart rate (HR) responses to apneas allowing to compare extreme HR accelerations and decelerations between the groups.<br />Results: Average sleep-time HR was comparable in BB-naive (BB-) and BB-treated (BB+) patients. Direct comparisons showed that HR decelerations were also similar in the two subgroups (53.8±9.6 vs. 54.4±7.8 bpm; P=0.78, for BB- and BB+, respectively) however, BBs blunted the OSA-induced HR accelerations (82.3±12.2 vs. 74.3±10.0; P=0.003). After adjusting for baseline HR and magnitude of desaturations, HR decelerations were more evident in BB-naive group whereas tachycardic responses remained blunted in the BB+ group. The incidence of ectopies and conduction abnormalities were comparable across two groups.<br />Conclusions: Beta-blockers do not potentiate apnea-induced HR decelerations, attenuate apnea-induced increases in heart rate and do not influence incidence of ectopies and conduction abnormalities in patients with hypertension and moderate-to-severe, untreated OSA.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Blood Pressure drug effects
Blood Pressure physiology
Female
Follow-Up Studies
Humans
Hypertension complications
Hypertension physiopathology
Male
Middle Aged
Polysomnography
Retrospective Studies
Sleep Apnea, Obstructive complications
Sleep Apnea, Obstructive physiopathology
Adrenergic beta-Antagonists administration & dosage
Electrocardiography drug effects
Heart Rate drug effects
Hypertension drug therapy
Sleep physiology
Sleep Apnea, Obstructive drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 202
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 26386925
- Full Text :
- https://doi.org/10.1016/j.ijcard.2015.08.139