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Improving pancreatic cancer diagnosis using circulating tumor cells: prospects for staging and single-cell analysis.
- Source :
-
Expert review of molecular diagnostics [Expert Rev Mol Diagn] 2015; Vol. 15 (11), pp. 1491-504. Date of Electronic Publication: 2015 Sep 21. - Publication Year :
- 2015
-
Abstract
- Pancreatic cancer (PC) is the fourth most common cause of cancer-related death in the USA, primarily due to late presentation coupled with an aggressive biology. The lack of adequate biomarkers for diagnosis and staging confound clinical decision-making and delay potentially effective therapies. Circulating tumor cells (CTCs) are a promising new biomarker in PC. Preliminary studies have demonstrated their potential clinical utility, and newer CTC isolation platforms have the potential to provide clinicians access to tumor tissue in a reliable, real-time manner. Such a 'liquid biopsy' has been demonstrated in several cancers, and small studies have demonstrated its potential applications in PC. This article reviews the available literature on CTCs as a biomarker in PC and presents the latest innovations in CTC research as well as their potential applications in PC.
- Subjects :
- Biomarkers, Tumor
Early Detection of Cancer methods
Humans
Molecular Diagnostic Techniques
Neoplasm Staging
Neoplastic Cells, Circulating pathology
Pancreatic Neoplasms genetics
Pancreatic Neoplasms pathology
Pancreatic Neoplasms therapy
Precision Medicine methods
Prognosis
Single-Cell Analysis methods
Neoplastic Cells, Circulating metabolism
Pancreatic Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8352
- Volume :
- 15
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Expert review of molecular diagnostics
- Publication Type :
- Academic Journal
- Accession number :
- 26390158
- Full Text :
- https://doi.org/10.1586/14737159.2015.1091311