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Iterative exponential growth of stereo- and sequence-controlled polymers.
- Source :
-
Nature chemistry [Nat Chem] 2015 Oct; Vol. 7 (10), pp. 810-5. Date of Electronic Publication: 2015 Sep 07. - Publication Year :
- 2015
-
Abstract
- Chemists have long sought sequence-controlled synthetic polymers that mimic nature's biopolymers, but a practical synthetic route that enables absolute control over polymer sequence and structure remains a key challenge. Here, we report an iterative exponential growth plus side-chain functionalization (IEG+) strategy that begins with enantiopure epoxides and facilitates the efficient synthesis of a family of uniform >3 kDa macromolecules of varying sequence and stereoconfiguration that are coupled to produce unimolecular polymers (>6 kDa) with sequences and structures that cannot be obtained using traditional polymerization techniques. Selective side-chain deprotection of three hexadecamers is also demonstrated, which imbues each compound with the ability to dissolve in water. We anticipate that these new macromolecules and the general IEG+ strategy will find broad application as a versatile platform for the scalable synthesis of sequence-controlled polymers.
Details
- Language :
- English
- ISSN :
- 1755-4349
- Volume :
- 7
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26391080
- Full Text :
- https://doi.org/10.1038/nchem.2346