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A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2015 Dec; Vol. 24 (12), pp. 1838-43. Date of Electronic Publication: 2015 Sep 24. - Publication Year :
- 2015
-
Abstract
- Background: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein-Barr virus (EBV) status, particularly within the MHC region.<br />Methods: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls.<br />Results: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and cHL. Although strongly associated with EBV-positive cHL [OR, 2.33; 95% confidence interval (CI), 1.83-2.97; P = 7 × 10(-12)], there was little evidence for association between rs6457715 and the EBV-negative subgroup of cHL (OR, 1.06; 95% CI, 0.92-1.21), indicating that this association was specific to the EBV-positive subgroup (Phet < P = 10(-8)). Furthermore, the association was limited to EBV-positive cHL subgroups within mixed cell (MCHL) and nodular sclerosis subtypes (NSHL), suggesting that the association is independent of histologic subtype of cHL.<br />Conclusions: rs6457715, located near the HLA-DPB1 gene, is associated with EBV-positive cHL and suggests this region as a novel susceptibility locus for cHL.<br />Impact: This expands the number of genetic variants that are associated with cHL and provides additional evidence for a critical and specific role of EBV in the etiology of this disease.<br /> (©2015 American Association for Cancer Research.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Epstein-Barr Virus Infections epidemiology
Epstein-Barr Virus Infections pathology
Epstein-Barr Virus Infections virology
Female
Genetic Predisposition to Disease
Hodgkin Disease epidemiology
Hodgkin Disease pathology
Humans
Major Histocompatibility Complex genetics
Male
Middle Aged
Netherlands epidemiology
Polymorphism, Single Nucleotide
Scandinavian and Nordic Countries epidemiology
Young Adult
Chromosomes, Human, Pair 6
Epstein-Barr Virus Infections genetics
Hodgkin Disease genetics
Hodgkin Disease virology
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 24
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26404960
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-15-0534