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A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2016; Vol. 57 (6), pp. 1406-12. Date of Electronic Publication: 2015 Nov 16. - Publication Year :
- 2016
-
Abstract
- Overall, more than 50% of marginal zone lymphoma (MZL) patients experience a relapse within 10 years. This phase II trial was conducted to assess the efficacy and safety of oxaliplatin-prednisone (Ox-P) chemotherapy for patients with relapsed or refractory MZL. Patients received oxaliplatin 130 mg/m(2) on day 1 and prednisone 100 mg/day on days 1-5 of each cycle. A total of 38 patients were enrolled. The median age of the 34 (16 males, 18 females) evaluated patients was 53 (range = 27-74) years. There were seven complete responses (20.6%) and 15 partial responses (44.1%) (Overall response rate = 64.7%). No treatment-related deaths occurred. The median progression-free survival was 14.2 months (95% CI = 2.1-26.3 months); 3-year overall survival rate was 77.7%. Thus, salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols adverse effects
Combined Modality Therapy
Drug Resistance, Neoplasm
Female
Humans
Lymphoma, B-Cell, Marginal Zone mortality
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Organoplatinum Compounds administration & dosage
Oxaliplatin
Prednisone administration & dosage
Prognosis
Recurrence
Retreatment
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Lymphoma, B-Cell, Marginal Zone diagnosis
Lymphoma, B-Cell, Marginal Zone drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 57
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 26413982
- Full Text :
- https://doi.org/10.3109/10428194.2015.1099650