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A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2015 Nov; Vol. 27 (42), pp. 6637-43. Date of Electronic Publication: 2015 Sep 28. - Publication Year :
- 2015
-
Abstract
- New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- 1-Carboxyglutamic Acid chemistry
Animals
Anti-Inflammatory Agents chemistry
Collagenases metabolism
Disease Models, Animal
Drug Delivery Systems
Ferritins chemistry
Fetal Blood
Human Embryonic Stem Cells
Humans
Leukocytes drug effects
Leukocytes physiology
Lipopolysaccharides
Male
Mice, Inbred C57BL
Protein C chemistry
Receptor, PAR-1 metabolism
Sepsis metabolism
Sepsis mortality
Anti-Inflammatory Agents administration & dosage
Nanostructures chemistry
Peptide Fragments administration & dosage
Protein C administration & dosage
Receptors, Thrombin agonists
Sepsis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 27
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 26414883
- Full Text :
- https://doi.org/10.1002/adma.201503093