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Immunoproteomic technology offers an extraordinary diagnostic approach for Toxoplasma gondii infection.

Authors :
El-Ashram S
Yin Q
Barta JR
Khan J
Liu X
Suo X
Source :
Journal of microbiological methods [J Microbiol Methods] 2015 Dec; Vol. 119, pp. 18-30. Date of Electronic Publication: 2015 Sep 28.
Publication Year :
2015

Abstract

Immunoproteomic technology offers an exceptional tool to fill the blanks that still exist in diagnosis of Toxoplasma gondii infection despite its annotated sequence. The pitfalls of serological assays and current immunoproteomic approaches are accentuated, and new approaches are presented to improve the signal and to eliminate the noise produced by blocking-specific background. This review also highlights examples where immunoproteomic studies have contributed to broaden our understanding of toxoplasmosis diagnosis. Further promising solutions, which immunoproteomic technology can grant for toxoplasmosis diagnosis are part of an intense discussion.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-8359
Volume :
119
Database :
MEDLINE
Journal :
Journal of microbiological methods
Publication Type :
Academic Journal
Accession number :
26415530
Full Text :
https://doi.org/10.1016/j.mimet.2015.09.011