Back to Search
Start Over
Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study.
- Source :
-
Medicine [Medicine (Baltimore)] 2015 Sep; Vol. 94 (39), pp. e1644. - Publication Year :
- 2015
-
Abstract
- Studies have suggested that statin use is related to cancer risk and prostate cancer mortality. We conducted a population-based cohort study to determine whether using statins in prostate cancer patients is associated with reduced all-cause mortality rates. Data were obtained from the Taiwan National Health Insurance Research Database. The study cohort comprised 5179 patients diagnosed with prostate cancer who used statins for at least 6 months between January 1, 1998 and December 31, 2010. To form a comparison group, each patient was randomly frequency-matched (according to age and index date) with a prostate cancer patient who did not use any type of statin-based drugs during the study period. The study endpoint was mortality. The hazard ratio (HR) and 95% confidence interval (CI) were estimated using Cox regression models. Among prostate cancer patients, statin use was associated with significantly decreased all-cause mortality (adjusted HR = 0.65; 95% CI = 0.60-0.71). This phenomenon was observed among various types of statin, age groups, and treatment methods. Analyzing the defined daily dose of statins indicated that both low- and high-dose groups exhibited significantly decreased death rates compared with nonusers, suggesting a dose-response relationship. The results of this population-based cohort study suggest that using statins reduces all-cause mortality among prostate cancer patients, and a dose-response relationship may exist.
- Subjects :
- Aged
Aged, 80 and over
Case-Control Studies
Cohort Studies
Databases, Factual
Dose-Response Relationship, Drug
Humans
Male
Middle Aged
National Health Programs
Prostatic Neoplasms diagnosis
Prostatic Neoplasms therapy
Survival Analysis
Taiwan epidemiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Prostatic Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 94
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26426656
- Full Text :
- https://doi.org/10.1097/MD.0000000000001644