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The Impact of Age on 5-Year Outcomes After Atrial Fibrillation Catheter Ablation.
- Source :
-
Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2016 Feb; Vol. 27 (2), pp. 141-6. Date of Electronic Publication: 2015 Nov 20. - Publication Year :
- 2016
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Abstract
- Background: Catheter ablation of atrial fibrillation (AF) is an established therapeutic rhythm approach in symptomatic patients. Many studies have shown that age has little to no impact on outcomes during the first year after ablation. However, AF is a disease of aging and age-based substrate for arrhythmia is likely to progress. To this regard, we examined patients with 5-year outcome data following an index AF ablation procedure to define the impact of age on long-term outcomes.<br />Methods: A total of 923 patients that underwent their index AF ablation and had 5 years of follow-up were studied. Patients were followed up for atrial flutter/AF recurrence, heart failure, stroke, death, and cardiac function. Patients were separated and compared in 5 age-based groups (<50, 51-60, 61-70, 71-80, >80).<br />Results: The average age of the population was 66 ± 11 years and 59% were male. The AF was paroxysmal in 55%, persistent in 27%, and longstanding persistent in 18%. Older patients were more likely female and had higher rates of cardiovascular diseases. For every 10-year increase in age there was a higher multivariate-adjusted risk of atrial flutter/AF recurrence (HR: 1.13, P = 0.01), death (HR:1.91, P < 0.0001), and major adverse cardiac events (HR: 1.09, P = 0.07). Although atrial flutter/AF recurrence rates by age were similar at 1 year, at 5 years, younger patients had significantly lower rates of recurrences.<br />Conclusion: Age significantly impacts outcomes after AF ablation when analyzed with long-term follow-up. These data highlight the progressive nature of AF and the need to consider interventions early.<br /> (© 2015 Wiley Periodicals, Inc.)
- Subjects :
- Action Potentials
Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation diagnosis
Atrial Fibrillation mortality
Atrial Fibrillation physiopathology
Atrial Flutter etiology
Chi-Square Distribution
Disease-Free Survival
Female
Heart Failure etiology
Heart Rate
Humans
Male
Middle Aged
Multivariate Analysis
Patient Selection
Proportional Hazards Models
Recurrence
Risk Factors
Stroke etiology
Time Factors
Treatment Outcome
Utah
Atrial Fibrillation surgery
Catheter Ablation adverse effects
Catheter Ablation mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1540-8167
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 26443666
- Full Text :
- https://doi.org/10.1111/jce.12849