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Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy.
- Source :
-
Nanoscale [Nanoscale] 2016 Jul 07; Vol. 8 (25), pp. 12504-9. Date of Electronic Publication: 2015 Oct 07. - Publication Year :
- 2016
-
Abstract
- To date, the delivery of nano-sized therapeutic agents to cancers largely relies on enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. However, nano-sized agents delivered in this way have demonstrated limited success in oncology due to the relatively small magnitude of the EPR effect. For achieving superior delivery of nano-sized agents, super-enhanced permeability and retention (SUPR) effects are needed. Near infrared photo-immunotherapy (NIR-PIT) is a recently reported therapy that treats tumors with light therapy and subsequently causes an increase in nano-drug delivery up to 24-fold compared with untreated tumors in which only the EPR effect is present. SUPR effects could enhance delivery into tumor beds of a wide variety of nano-sized agents including particles, antibodies, and protein binding small molecular agents. Therefore, taking advantage of the SUPR effects after NIR-PIT may be a promising avenue to utilize a wide variety of nano-drugs in a highly effective manner.
Details
- Language :
- English
- ISSN :
- 2040-3372
- Volume :
- 8
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Nanoscale
- Publication Type :
- Academic Journal
- Accession number :
- 26443992
- Full Text :
- https://doi.org/10.1039/c5nr05552k