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Injectable 2D MoS2 -Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2015 Nov 25; Vol. 27 (44), pp. 7117-22. Date of Electronic Publication: 2015 Oct 08. - Publication Year :
- 2015
-
Abstract
- MoS2 nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS2 /DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2 /DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Cell Line
Doxorubicin chemistry
Doxorubicin therapeutic use
Injections
Lactic Acid chemistry
Lasers
Mice
Models, Molecular
Molecular Conformation
Neoplasms drug therapy
Polyglycolic Acid chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Prostheses and Implants
Disulfides chemistry
Drug Carriers chemistry
Hyperthermia, Induced methods
Infrared Rays
Molybdenum chemistry
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 27
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 26447460
- Full Text :
- https://doi.org/10.1002/adma.201503869