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Signs and Related Mechanisms of Ethanol Hepatotoxicity.

Authors :
Dinis-Oliveira RJ
Mãgalhaes T
Queirós O
Proença JB
Moreira R
de Lourdes Bastos M
Carvalho F
Source :
Current drug abuse reviews [Curr Drug Abuse Rev] 2015; Vol. 8 (2), pp. 86-103.
Publication Year :
2015

Abstract

Ethanol is the most abused psychoactive substance. Accordingly to World Health Organization ethanol ranks among the top five risk factors for disease, disability and death (3.3 million/year) throughout the world. This manuscript highlights and critically analyses clinical and forensic signs related to hepatoxicity of ethanol that may lead to suspected of abuse. Namely, steatosis, jaundice, cirrhosis, hemorrhoids, esophageal varices caput medusae, ascites, petechiae, ecchymoses, splenomegaly, hemochromatosis, xanthelasma, nutritional deficiency, testicular atrophy, gynecomastia and dilated congestive cardiomyopathy are discussed and related to the toxic mechanism of ethanol.

Details

Language :
English
ISSN :
1874-4745
Volume :
8
Issue :
2
Database :
MEDLINE
Journal :
Current drug abuse reviews
Publication Type :
Academic Journal
Accession number :
26452450
Full Text :
https://doi.org/10.2174/1874473708666150916113352