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Particle-based platforms for malaria vaccines.
- Source :
-
Vaccine [Vaccine] 2015 Dec 22; Vol. 33 (52), pp. 7518-24. Date of Electronic Publication: 2015 Oct 11. - Publication Year :
- 2015
-
Abstract
- Recombinant subunit vaccines in general are poor immunogens likely due to the small size of peptides and proteins, combined with the lack or reduced presentation of repetitive motifs and missing complementary signal(s) for optimal triggering of the immune response. Therefore, recombinant subunit vaccines require enhancement by vaccine delivery vehicles in order to attain adequate protective immunity. Particle-based delivery platforms, including particulate antigens and particulate adjuvants, are promising delivery vehicles for modifying the way in which immunogens are presented to both the innate and adaptive immune systems. These particle delivery platforms can also co-deliver non-specific immunostimodulators as additional adjuvants. This paper reviews efforts and advances of the Particle-based delivery platforms in development of vaccines against malaria, a disease that claims over 600,000 lives per year, most of them are children under 5 years of age in sub-Sahara Africa.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adjuvants, Immunologic
Antigens, Protozoan immunology
Humans
Malaria Vaccines administration & dosage
Vaccines, Subunit administration & dosage
Vaccines, Subunit immunology
Vaccines, Virus-Like Particle administration & dosage
Malaria Vaccines immunology
Nanoparticles
Vaccines, Virus-Like Particle immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 33
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 26458803
- Full Text :
- https://doi.org/10.1016/j.vaccine.2015.09.097