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Homocysteine in Chronic Kidney Disease.
- Source :
-
Advances in clinical chemistry [Adv Clin Chem] 2015; Vol. 72, pp. 77-106. Date of Electronic Publication: 2015 Aug 24. - Publication Year :
- 2015
-
Abstract
- Hyperhomocysteinemia occurs in chronic- and end-stage kidney disease at the time when dialysis or transplant becomes indispensable for survival. Excessive accumulation of homocysteine (Hcy) aggravates conditions associated with imbalanced homeostasis and cellular redox thereby resulting in severe oxidative stress leading to oxidation of reduced free and protein-bound thiols. Thiol modifications such as N-homocysteinylation, sulfination, cysteinylation, glutathionylation, and sulfhydration control cellular responses that direct complex metabolic pathways. Although cysteinyl modifications are kept low, under Hcy-induced stress, thiol modifications persist thus surpassing cellular proteostasis. Here, we review mechanisms of redox regulation and show how cysteinyl modifications triggered by excess Hcy contribute development and progression of chronic kidney disease. We discuss different signaling events resulting from aberrant cysteinyl modification with a focus on transsulfuration.<br /> (© 2015 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 0065-2423
- Volume :
- 72
- Database :
- MEDLINE
- Journal :
- Advances in clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26471081
- Full Text :
- https://doi.org/10.1016/bs.acc.2015.07.002