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Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Sep; Vol. 159 (5), pp. 642-5. Date of Electronic Publication: 2015 Oct 16. - Publication Year :
- 2015
-
Abstract
- The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
- Subjects :
- Adenylyl Cyclases metabolism
Animals
Cell Differentiation drug effects
Cell Proliferation drug effects
Cyclic AMP antagonists & inhibitors
Dideoxyadenosine analogs & derivatives
Dideoxyadenosine pharmacology
Enzyme Inhibitors pharmacology
Gene Expression Regulation
I-kappa B Kinase antagonists & inhibitors
I-kappa B Kinase metabolism
Male
Mesenchymal Stem Cells cytology
Mesenchymal Stem Cells metabolism
Mice
Mice, Inbred CBA
Primary Cell Culture
Signal Transduction
Stem Cells
Thiophenes pharmacology
Adenylyl Cyclases genetics
Alkaloids pharmacology
Cyclic AMP metabolism
I-kappa B Kinase genetics
Mesenchymal Stem Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 159
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26472093
- Full Text :
- https://doi.org/10.1007/s10517-015-3036-0