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Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.
- Source :
-
The Journal of rheumatology [J Rheumatol] 2015 Dec; Vol. 42 (12), pp. 2419-26. Date of Electronic Publication: 2015 Oct 15. - Publication Year :
- 2015
-
Abstract
- Objective: Autoantibodies to the dense fine speckled 70 kDa antigen (DFS70) are reported to be more common in individuals who do not have an antinuclear antibody (ANA)-associated rheumatic disease (AARD) than in patients with AARD. The frequency of anti-DFS70 antibodies has been thoroughly studied in adult but not in pediatric populations. The primary objective of this observational study was to determine the frequency of anti-DFS70 in pediatric AARD and reference cohorts.<br />Methods: Sera from 743 children with AARD and related conditions, and 345 samples from reference cohorts (healthy children and those being investigated for AARD) were studied for anti-DFS70 autoantibodies as measured by a chemiluminescence immunoassay. A de-identified administrative database was used to retrieve demographic, serologic, and clinical data.<br />Results: Anti-DFS70 antibodies were seen in 2.1% of healthy children and in 4.5% of sera from pediatric individuals referred for ANA testing. The frequency of anti-DFS70 was highest in juvenile localized scleroderma (LS; 4/29, 13.8%), juvenile dermatomyositis (JDM; 2/11, 18.2%), childhood systemic lupus erythematosus (cSLE; 19/331, 5.7%), diffuse cutaneous systemic sclerosis (1/22, 4.5%), celiac disease (2/49, 4.1%), and juvenile idiopathic arthritis (JIA; 5/202, 2.5%). Of note, anti-DFS70 antibodies were observed in 3/26 children (11.5%) with uveitis and JIA-associated uveitis.<br />Conclusion: The frequency of anti-DFS70 autoantibodies in healthy pediatric subjects is within the lower range of that reported in adults. Anti-DFS70 antibodies can be found in childhood SSc and cSLE, but has a remarkably high frequency in children with LS, JDM, and uveitis.
- Subjects :
- Adolescent
Age Factors
Antibodies, Antinuclear blood
Autoantibodies blood
Autoimmune Diseases immunology
Autoimmune Diseases physiopathology
Case-Control Studies
Child
Child, Preschool
Disease Progression
Female
Fluorescent Antibody Technique, Indirect methods
Follow-Up Studies
Humans
Likelihood Functions
Male
Reference Values
Rheumatic Diseases blood
Rheumatic Diseases physiopathology
Risk Assessment
Sex Factors
Adaptor Proteins, Signal Transducing immunology
Antibodies, Antinuclear immunology
Autoantibodies immunology
Rheumatic Diseases immunology
Transcription Factors immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 42
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 26472409
- Full Text :
- https://doi.org/10.3899/jrheum.150567